A chiaroscuro woodcut reproducing, in reverse, a design by Raphael for the fresco God appears to Isaac painted by the workshop of Raphael (c.1517-19) in the vault of the fourth bay of the Raphael Loggia in the Vatican. Signed with printmaker's name at centre bottom and inscribed: Ex Raphaelis Urbinatis Schede. Trimmed on all sides. For another impression of this woodcut, see RCIN 853437.

Zanetti revived the chiaroscuro woodcut, a prevalent technique of sixteenth-century Italian printmaking. Zanetti published a collection of chiaroscuro woodcuts, primarily after works by Parmigianino, but also including some after Raphael, in the late 1720s under the title Diversarum Iconum and again in a third edition of 1749 with the title 'Raccolta di varie stampe...'. See RCINs 853407, 853429, 853437, 853457, 853471 and 853531 for other chiaroscuro woodcuts by Zanetti after Loggia frescoes.

Höper (2001) cites the drawing now in the Staatsgalerie, Stuttgart (see RCIN 853440 for a photograph), as that used by Zanetti for his engraving.