Antonio Priuli was Doge from 1618 to 1623. Here he is shown in three-quarter-length, standing, facing to to the left. He wears gold patterned Ducal robes with an ermine cape and a gold hat. There is a column at the left and a curtain at the right. The Doge is pointing to the left with his right hand and holding a folded letter in his left hand; it is possible that the letters on the paper were once decipherable.

This was one of four portraits of Doges acquired by Sir Henry Wotton during his tenure as ambassador in Venice. The paintings were hung in Wotton's dining room at Eton College and bequeathed to Charles I in 1637, Wotton's will describes: 'four pictures at large of those Dukes of Venice, in whose time I was there employed with their names written on the back side, which hang in my ordinary Dining-room, done after the life by Eduardo Fialetto'.